In Vivo Control of Differentiation of Myeloid Leukemic Cells by Cyclosporine A and Recombinant Interleukin-la

There are different types of hematopoietic regulatory proteins that regulate the multiplication and differentiation of normal myeloid cells. These different types include four growth-inducing proteins called colony-stimulating factors (CSF). including interleukin-3 (11-3). or macrophage and granulocyte inducers. type 1 (MGI-i ); another type (called MGI-2) that induces myeloid differentiation of normal myeloid cells without inducing myeloid cell multiplication; and interleukin-i (IL-i ), which can act on myeloid precursor cells. Different clones of myeloid leukemic cells can differ in their ability to be induced to undergo terminal cell differentiation by different hematopoietic regulatory proteins. We have now studied the ability of cyclosporine A and recombinant IL-i a to regulate in vivo differentiation of different clones of myeloid leukemic cells that are either